Dipl.-Biol. Siegfried J.W. Ruppert

U.S. Rechtsanwalt | U.S. Patentanwalt

Wissenschaftliche Publikationen

Im Rahmen seiner wissenschaftlichen Arbeiten war Dr. Ruppert in die in den unten gelisteten Publikationen beschriebenen Forschungsprojekte involviert.

  • Shao, Z., Siegert, J.L., Ruppert, S. and Robbins, P.D. (1997). Rb interacts with TAFII250/TFIID through multiple domains distinct from E2F and viral oncoprotein binding regions.  Oncogene 15, 385-392.
  • Marsters, S.A., Pitti, R.M., Donahue, C.J., Ruppert, S., Roberts, P., Bauer, K.D. and Ashkenazi, A. (1996). Activation of apoptosis by Apo-2 ligand is independent of FADD but blocked by CrmA.  Current Biology 6, 750-752.
  • Pitti, R.M., Marsters, S.A., Ruppert, S., Donahue, C.J., Moore, A. and Ashkenazi, A. (1996). Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271, 12687-12690.
  • Dikstein, R., Ruppert, S. and Tjian, R. (1996). TAFII250 is a bipartite protein kinase that phosphorylates the basal transcription factor RAP74.  Cell 84, 781-790.
  • Ruppert, S. and Tjian, R. (1995). Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation. Genes & Dev. 9, 2747-2755.
  • Shao, Z., Ruppert, S. and Robbins, P.D. (1995). The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250. Proc. Natl. Acad. Sci. USA 92, 3115-3119.
  • Tansey, W.P., Ruppert, S., Tjian, R. and Herr, W. (1994). Multiple regions of TBP participate in the response to transcriptional activators in vivo. Genes & Dev. 8, 2756-2769.
  • Kelsey, G., Ruppert, S., Beermann, F., Grund, C., Tanguay, R.M. and Schütz, G. (1993). Rescue of mice homozygous for lethal albino deletions: Implications for an animal model for human liver disease tyrosinaemia type 1. Genes & Dev. 7 (12a), 2285-2297.
  • Shelly, L.L., Lei, K.-J., Pan, C.-J., Sakata, S.F., Ruppert, S., Schütz, G. and Chou, J.Y. (1993). Isolation of the gene for murine glucose-6-phosphatase, the enzyme deficient in glycogen storage disease Type 1A.  J. Biol. Chem. 268, 21482-21485.
  • Weinzierl, R.O.J., Ruppert, S., Dynlacht, B.D., Tanese, N. and Tjian, R. (1993). Cloning and expression of Drosophila TAFII60 and human TAFII70 reveals conserved interactions with other subunits of TFIID. EMBO Journal 12 (13), 5303-5309.
  • Ruppert, S., Wang, E.H. and Tjian, R. (1993). Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation. Nature 362, 175-179.
  • Sakata, S.F., Shelly, L.L. Ruppert, S., Schütz, G. and Chou, J.Y. (1993). Cloning and expression of murine S-adenosylmethionine synthetase. J. Biol. Chem. 268, 13978-13986.
  • Beermann, F., Schedl, A., Ruppert, S., Ganss, R., Schmid, E., Klueppel, M., Hummler, E. and Schütz, G. (1993). The mouse tyrosinase gene: Pigment cell-specific gene expression in transgenic mice. In: Pharmacology of the Skin, Vol. 5, From Molecular Biology to Therapeutics, B.A. Bernhard and B. Shroot (eds), Karger, Basel, 57-62.
  • Kelsey, G., Ruppert, S., Schedl, A., Schmid, E., Thies, E. and Schütz, G. (1992). Multiple effects on liver-specific gene expression in albino lethal mice caused by deficiency of an enzyme in tyrosine metabolism. Journal of Cell Science – Supplement 16, 117-122.
  • Rosewicz, S., Vogt, D., Harth, N., Grund, C., Franke, W.W., Ruppert, S., Schweitzer, E., Riecken, E.O. and Wiedenmann, B. (1992). An amphicrine pancreatic cell line: AR42J cells combine exocrine and neuroendocrine properties. European Journal of Cell Biology 59, 80-91.
  • Beermann, F., Schmid, E., Ganss, R., Schütz, G. and Ruppert, S. (1992). Molecular characterization of the mouse tyrosinase gene: Pigment cell-specific expression in transgenic mice. Pigment Cell Research 5, 295-9.
  • Ruppert, S., Kelsey, G., Schedl, A., Schmid, E., Thies, E. and Schütz, G. (1992). Deficiency of an enzyme of tyrosine metabolism underlies altered gene expression in newborn liver of lethal albino mice.  Genes & Dev. 6, 1430-1443.
  • Schedl, A., Ruppert, S., Kelsey, G., Thies, E., Niswander, L., Magnuson, T., Klebig, M.L., Rinchik, E.M. and Schütz, G. (1992). Chromosome jumping from flanking markers defines the minimal region for alf/hsdr-1 within the albino-deletion complex. Genomics 14, 288-297.
  • Kelsey, G., Schedl, A., Ruppert, S., Klebig, M.L., Niswander, L., Magnuson, T., Rinchik, E.M. and Schütz, G. (1992). Physical mapping of the albino-deletion complex in the mouse to localize alf/hsdr-1, a locus required for neonatal survival. Genomics 14, 275-287.
  • Cole, T., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Schütz, G. and Ruppert, S. (1992). The mouse CREB (cAMP responsive element binding protein) gene: structure, promoter analysis, and chromosomal localization. Genomics 13 (4), 974-982.
  • Ruppert, S., Cole, T.J., Boshart, M., Schmid, E. and Schütz, G. (1992). Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in spermatocytes. EMBO Journal 11, 1503-1512.
  • Sharan, S.K., Holdener-Kenny, B., Ruppert, S., Schedl, A., Kelsey, G., Rinchik, E.M. and Magnuson, T.  (1991). The albino-deletion complex of the mouse: molecular mapping of deletion breakpoints that define regions necessary for development of the embryonic and extraembryonic ectoderm. Genetics 129, 825-832.
  • Beermann, F., Ruppert, S., Hummler, E. and Schütz, G. (1991). Tyrosinase as a marker for transgenic mice. Nucleic Acids Res. 19, 958.
  • Klüppel, M., Beermann, F., Ruppert, S., Schmid, E., Hummler, E. and Schütz, G. (1991). The mouse tyrosinase promoter is sufficient for expression in melanocytes and in the pigmented epithelium of the retina. Proc. Natl. Acad. Sci. USA 88, 3777-3781.
  • Chou, J.Y., Ruppert, S., Shelly, L.L. and Pan, C.-J. (1991). Isolation and characterization of mouse hepatocyte lines carrying a lethal albino deletion. J. Biol. Chem. 266, 5716-5722.
  • Niswander, L., Kelsey, G., Schedl, A., Ruppert, S., Sharan, S.K., Holdener-Kenny, B., Rinchik, E.M., Edström, J.-E. & Magnuson, T. (1991). Molecular mapping of albino deletions associated with early embryonic lethality in the mouse. Genomics 9, 162-169.
  • Nitsch, D., Ruppert, S., Kelsey, G., Schedl, A., Weih, F., Stewart, F., Strähle, U., Schmid, W., deVack, C., Reik, A., Boshart, M. and Schütz, G. (1991). Hormonal and liver-specific control of expression of the tyrosine aminotransferase gene. In: Molecular Aspects of Cellular Regulation. Vol. 6 The Hormonal Control Regulation of Gene Transcription. p 223-234. P. Cohen and J.G. Foulkes (eds). Elsevier Science. Publishers B.V. Amsterdam, The Netherlands.
  • Beermann, F., Ruppert, S., Hummler, E., Bosch, F.X., Müller, G., Rüther, U. and Schütz, G. (1990). Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice. EMBO Journal9, 2819-2826.
  • Schöler, H.R., Ruppert, S., Suzuki, N., Chowdhury, K. and Gruss, P. (1990). New type of POU domain in germ line-specific protein Oct-4. Nature 344, 435-439.
  • Ruppert, S., Boshart, M., Bosch, F.X., Schmid, W., Fournier, K. and Schütz. G. (1990). Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes.  Cell 61, 895-904.
  • Ryseck, R.-P., Macdonald-Bravo, H., Mattéi, M.-G., Ruppert, S. and Bravo, R. (1989). Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor. EMBO Journal 11, 3327-3335.
  • Kelsey, G.D., Ruppert, S., Boshart, M., Schedl, A., Schmid, W. and Schütz, G. (1989). The albino perinatal lethal deletion: Identification of affected mRNAs and mapping of the locus by pulsed-field gel electrophoresis.  NATO ASI Series, Vol. H34. Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation. pp 47-62.
  • Müller, M.M., Ruppert, S., Schaffner, W. and Matthias, P. (1988). A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells.  Nature 336, 544-551.
  • Müller, G., Ruppert, S., Schmid, E. and Schütz, G. (1988). Functional analysis of alternatively spliced tyrosinase gene transcripts. EMBO Journal 9, 2723-2730.
  • Ruppert, S., Müller, G., Kwon, B. and Schütz, G. (1988). Multiple transcripts of the mouse tyrosinase gene are generated by alternative splicing. EMBO Journal9, 2715-2722.
  • Becker, P.B., Ruppert, S. and Schütz, G. (1987). Genomic footprinting reveals cell type-specific DNA binding of ubiquitous factors. Cell 51, 435-443.
  • Müller, G., Scherer, G., Zentgraf, H., Ruppert, S., Herrmann, B., Lehrach, H. and Schütz, G. (1985). Isolation, characterization and chromosomal mapping of the mouse tyrosine aminotransferase gene. J. Mol. Biol. 184, 367-373.
  • Ruppert, S., Scherer, G. and Schütz, G. (1984). Recent gene conversion involving bovine vasopressin and oxytocin precursor genes suggested by nucleotide sequence. Nature 308, 554-557.
  • Land H., Grez, M., Ruppert, S., Schmale, H., Rehbein, M., Richter, D. and Schütz, G. (1983). Deduced amino acid sequence from the bovine oxytocin-neurophysin I precursor cDNA. Nature 302, 342-344.

U.S. Patente

Dr. Ruppert’s wissenschaftliche Arbeiten an der Universität Kalifornien in Berkeley und bei der U.S. Biotechfirma Genentech, Inc. führten u.a., zu den hier aufgeführten U.S. Patenten:

  • Ruppert, S., (1999) United States Patent No. 5,891,637 “Construction of full-length cDNA libraries.”
  • Tjian, R., Comai, L., Dynlacht, B.D., Hoey, T., Ruppert, S., Tanese, N., Wang, E., Weinzierl, R.O.J. (1997) United States Patent No. 5,637,686 “TATA-binding protein associated factors, nucleic acids.”
  • Tjian, R., Comai, L., Dynlacht, B.D., Hoey, T., Ruppert, S., Tanese, N., Wang, E., Weinzierl, R.O.J. (1996) United States Patent No. 5,534,410 “TATA-binding protein associated factors drug screens.”